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    Botox injections and dermal fillers to treat wrinkles could be a thing of the past, if a new natural treatment is proven to work.<br>Scientists believe healthy skin cells could one day be ‘banked’ and used later in life, when the effects of ageing have taken their toll. <br>Researchers tested the method on mice – delivered deep into their skin through jets of air, which smoothed out their wrinkles within three weeks. <br>It was also 30 per cent more effective than one of the most advanced anti-ageing methods which uses stem cells, according to the team at North Caroline State University.<br>The developers hope the technique will also works on humans, paving the way for 식물 엑소즘 a needle-free method to curing wrinkles<br>/p>The pioneering method works by harvesting skin cells and a molecule within them that can boost collagen production<br>/p> The end of wrinkles may be in sight as scientists at North Caroline State University find a new approach was successful on mice.

    Pictured, 식물 엑소즘 their method compared with a c<br>olWrinkles are caused by the skin becoming more elastic as you age because the cells lose their ability to multiple and produce col<br>n.Collagen is a protein in the body that forms structures of the skin, hair and nails.

    It starts to decline at about age 25, accelerated by sun exposure and sm<br>g.There is no way to halt this, but scientists have endeavored to find ways of masking the creases – wrinkles – left beh<br>  RELATED ARTICLES

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    Researchers turned their attention to exosomes, which are secreted by cells in the body as a way of communic<br>g.They can transfer information such as DNA, RNA or proteins between cells, which can affect the function of the recipient cell. <br> Professor Ke Cheng and colleagues wanted to see if a dose of exosomes from human skin cells could reduce wrinkles in mic<br> Professor Cheng said: ‘Think of an exosome as an envelope with instructions inside – like one cell mailing a letter to another cell and telling it what <br>o.’In this case, the envelope contains microRNA, non-coding RNA that instructs the recipient cell to produce more collag<br> The researchers exposed mice to ultraviolet B (UVB) light, which accelerates aging and 식물 엑소즘 causes wrinkles to <br>.  After eight weeks of UVB exposure, the researchers administered exosomes from human skin cells to some of the <br>.  To avoid having to inject the exosomes with a needle, the team used a device that uses a jet of air to deliver medications deep into the <br>.  Three weeks later, the treated mice showed significantly thinner wrinkles than the untreated mice due to the boost in <br>agen.Skin from the mice treated with exosomes was around 20 per cent thicker than that of rodents which didn’t receive any t<br>ment.It was also five per cent thicker than the mice given MSC – an anti-wrinkle treatment using stem cells derived from bone <br>ow. MSCs – mesenchymal stem cells – are a particular type of adult stem cell being investigated as an ‘ultimate’ anti-ageing<br>rapy.There was 30 per cent more collagen production in skin treated with the exosomes than MSC trea<br>skin.The exosomes also worked better than topical retinoic acid, a standard anti-aging cream, used on another group o<br>ce. Professor Cheng said there are two major benefits to exosome treatments over conventional tr<br>ents.’One, you can use donor skin cells from anyone to grow and harvest these exosomes – they aren’t cells, so you don’t run the risk of rej<br>on. ‘And two, the treatment can be administered without needles – exosomes are small enough to be able to penetrate the skin via pressure, or jet injection <br>ods.’Botox temporarily reduces wrinkles by paralysing muscles in the face, which can cause a ‘frozen fa<br>look.It also comes with risks, as do dermal fillers, if not done pr<br>ly. Professor Chen said: ‘Our hope is eventually people may be able to “bank” skin samples and come back to them, or use donor exosome treatments that they can administer them<br>es. ‘We believe that this work is an important step toward potentiating future human clinical trials in the prevention and treatment of cutaneous <br>g.’ The findings were published in the journal American Chemical Societ<br>no. 

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